{"id":3985,"date":"2025-06-19T17:13:52","date_gmt":"2025-06-19T15:13:52","guid":{"rendered":"https:\/\/zencellowl.com\/?page_id=3985"},"modified":"2026-07-10T16:10:01","modified_gmt":"2026-07-10T14:10:01","slug":"esferoide-de-zencell","status":"publish","type":"page","link":"https:\/\/zencellowl.com\/es\/zencell-spheroid\/","title":{"rendered":"Zencell Esferoide"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3985\" class=\"elementor elementor-3985\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e21d3f0 e-flex e-con-boxed e-con e-parent\" data-id=\"e21d3f0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5c6c8c1 elementor-widget elementor-widget-html\" data-id=\"5c6c8c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Montserrat:wght@400;500;600;700;800&display=swap\" rel=\"stylesheet\">\n<style>\n.sp3 *, .sp3 *::before, .sp3 *::after { box-sizing: border-box; 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}\n.sp3-stat .n { font-size: 26px; font-weight: 800; color: var(--teal); line-height: 1; }\n.sp3-stat .l { font-size: 11px; color: rgba(255,255,255,.5); margin-top: 4px; }\n\n\/* SECTIONS *\/\n.sp3-w { max-width: 1100px; margin: 0 auto; padding: 72px 40px; }\n.sp3-label { font-size: 11px; font-weight: 700; letter-spacing: 2px; text-transform: uppercase; color: var(--teal); margin-bottom: 12px; }\n.sp3-h2 { font-size: clamp(22px,3vw,34px) !important; font-weight: 800 !important; color: var(--navy) !important; margin-bottom: 16px !important; line-height: 1.25 !important; }\n.sp3-h2 span { color: var(--teal); }\n.sp3-lead { font-size: 17px; color: var(--gray); max-width: 720px; margin-bottom: 40px; line-height: 1.7; }\n\n\/* WHY SPHEROIDS *\/\n.sp3-grid3 { display: grid; grid-template-columns: repeat(3,1fr); gap: 20px; margin-top: 40px; }\n.sp3-card { border: 1.5px solid var(--border); border-radius: 12px; padding: 26px 22px; background: var(--white); }\n.sp3-card-icon { width: 44px; height: 44px; 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background: var(--white); }\n.sp3-table tr:nth-child(even) td { background: var(--off); }\n.sp3-table tr:last-child td { border-bottom: none; }\n.sp3-table td:first-child { font-weight: 600; color: var(--navy); }\n.sp3-ok { color: var(--teal); font-weight: 700; }\n.sp3-mute { color: var(--gray); }\n.sp3-red { color: #c0392b; }\n\n\/* REFERENCE *\/\n.sp3-ref { border: 1.5px solid var(--border); border-radius: 12px; padding: 24px 28px; background: var(--white); display: flex; gap: 20px; align-items: flex-start; margin-top: 32px; }\n.sp3-ref-icon { width: 48px; height: 48px; border-radius: 10px; background: var(--teal-l); display: flex; align-items: center; justify-content: center; font-size: 22px; flex-shrink: 0; }\n.sp3-ref-text h4 { font-size: 15px; font-weight: 700; color: var(--navy); margin-bottom: 6px; }\n.sp3-ref-text p { font-size: 13px; color: var(--gray); line-height: 1.65; }\n\n\/* FAQ *\/\n.sp3-faq { margin-top: 40px; }\n.sp3-faq details { border-bottom: 1px solid var(--border); }\n.sp3-faq summary { padding: 18px 4px; font-size: 15px; font-weight: 600; color: var(--navy); cursor: pointer; list-style: none; display: flex; justify-content: space-between; align-items: center; }\n.sp3-faq summary::after { content: '+'; color: var(--teal); font-size: 20px; font-weight: 400; }\n.sp3-faq details[open] summary::after { content: '\u2212'; }\n.sp3-faq details p { padding: 0 4px 18px; font-size: 14px; color: var(--gray); line-height: 1.7; }\n.sp3-faq details p a { color: var(--teal); text-decoration: none; }\n\n\/* RELATED *\/\n.sp3-related { display: grid; grid-template-columns: repeat(3,1fr); gap: 16px; margin-top: 40px; }\n.sp3-rel { border: 1.5px solid var(--border); border-radius: 10px; padding: 22px; background: var(--white); text-decoration: none !important; display: block; transition: all .25s; }\n.sp3-rel:hover { border-color: var(--teal); box-shadow: 0 6px 20px rgba(58,174,160,0.1); transform: translateY(-2px); }\n.sp3-rel-tag { font-size: 10px; font-weight: 700; letter-spacing: 1.5px; text-transform: uppercase; color: var(--teal); margin-bottom: 8px; }\n.sp3-rel h4 { font-size: 14px; font-weight: 700; color: var(--navy); margin-bottom: 6px; line-height: 1.4; }\n.sp3-rel p { font-size: 13px; color: var(--gray); line-height: 1.6; }\n\n\/* CTA *\/\n.sp3-cta { background: var(--navy); padding: 72px 40px; text-align: center; }\n.sp3-cta h2 { font-size: clamp(22px,3vw,34px) !important; font-weight: 800 !important; color: var(--white) !important; margin-bottom: 14px !important; }\n.sp3-cta p { color: rgba(255,255,255,.65); font-size: 17px; max-width: 520px; margin: 0 auto 34px; }\n\n@media(max-width:900px) {\n  .sp3-grid3 { grid-template-columns: 1fr 1fr; }\n  .sp3-exp-grid { grid-template-columns: 1fr; }\n  .sp3-metrics { grid-template-columns: 1fr 1fr; }\n  .sp3-related { grid-template-columns: 1fr 1fr; }\n  .sp3-w { padding: 48px 22px; }\n  .sp3-hero { padding: 64px 22px 56px; }\n  .sp3-stat { padding: 20px; }\n}\n@media(max-width:600px) {\n  .sp3-grid3 { grid-template-columns: 1fr; }\n  .sp3-metrics { grid-template-columns: 1fr; }\n  .sp3-related { grid-template-columns: 1fr; }\n  .sp3-btn-ghost { margin-left: 0; margin-top: 10px; display: inline-block; }\n  .sp3-highlight { flex-direction: column; }\n}\n<\/style>\n\n<div class=\"sp3\">\n\n<!-- HERO -->\n<section class=\"sp3-hero\">\n  <div class=\"sp3-eyebrow\">zenCELL owl \u00b7 Spheroid & 3D Cell Culture<\/div>\n  <h1>Spheroid Live Cell Imaging \u2014 <span>Continuous, Inside Your Incubator<\/span><\/h1>\n  <p class=\"sp3-hero-lead\">Monitor spheroid growth, morphology, drug response and outgrowth dynamics continuously \u2014 brightfield, label-free, 24 wells simultaneously. No incubator disruption. No manual timepoints. Up to 14 days unattended.<\/p>\n  <a href=\"https:\/\/zencellowl.com\/live-remotedemo\/\" class=\"sp3-btn\">Book Free Demo<\/a>\n  <a href=\"https:\/\/zencellowl.com\/brightfield-live-cell-imaging\/\" class=\"sp3-btn sp3-btn-ghost\">All Applications \u2192<\/a>\n<\/section>\n\n<!-- STATS -->\n<div class=\"sp3-stats\">\n  <div class=\"sp3-stat\"><div class=\"n\">24<\/div><div class=\"l\">Wells simultaneously<\/div><\/div>\n  <div class=\"sp3-stat\"><div class=\"n\">10 min<\/div><div class=\"l\">Minimum imaging interval<\/div><\/div>\n  <div class=\"sp3-stat\"><div class=\"n\">14 days<\/div><div class=\"l\">Max. experiment duration<\/div><\/div>\n  <div class=\"sp3-stat\"><div class=\"n\">0<\/div><div class=\"l\">Fluorescent labels needed<\/div><\/div>\n  <div class=\"sp3-stat\"><div class=\"n\">50+<\/div><div class=\"l\">Publications validated<\/div><\/div>\n<\/div>\n\n<!-- WHY SPHEROIDS -->\n<div style=\"background:var(--off);\">\n  <div class=\"sp3-w\">\n    <div class=\"sp3-label\">Why 3D Spheroid Models?<\/div>\n    <h2 class=\"sp3-h2\">More Physiologically Relevant <span>Than 2D Cell Culture<\/span><\/h2>\n    <p class=\"sp3-lead\">Spheroids \u2014 three-dimensional multicellular aggregates \u2014 better mimic the cell-cell and cell-matrix interactions of living tissue. They are increasingly used in drug development, toxicology, oncology, and stem cell research as a bridge between simple 2D assays and complex animal models.<\/p>\n    <div class=\"sp3-grid3\">\n      <div class=\"sp3-card\">\n        <div class=\"sp3-card-icon\">\ud83e\uddec<\/div>\n        <h3>3D cell-cell interactions<\/h3>\n        <p>Spheroids form gradients of oxygen, nutrients, and metabolites \u2014 mimicking the microenvironment of tumors and tissue. Drug penetration and response differ fundamentally from 2D cultures.<\/p>\n      <\/div>\n      <div class=\"sp3-card\">\n        <div class=\"sp3-card-icon\">\ud83d\udc8a<\/div>\n        <h3>Better drug screening<\/h3>\n        <p>IC50 values from 3D spheroid assays are significantly more predictive of in vivo drug response than standard 2D cytotoxicity assays. Increasingly required in cancer drug development.<\/p>\n      <\/div>\n      <div class=\"sp3-card\">\n        <div class=\"sp3-card-icon\">\ud83d\udd2c<\/div>\n        <h3>Label-free monitoring<\/h3>\n        <p>Spheroid size, morphology, compactness and growth rate are all measurable in brightfield without fluorescent dyes \u2014 no protocol changes, no phototoxicity, no endpoint fixation.<\/p>\n      <\/div>\n      <div class=\"sp3-card\">\n        <div class=\"sp3-card-icon\">\ud83d\udcc8<\/div>\n        <h3>Kinetic growth data<\/h3>\n        <p>Continuous monitoring captures growth curves, outgrowth dynamics, and drug response onset in real time \u2014 not just a before\/after comparison at a single endpoint.<\/p>\n      <\/div>\n      <div class=\"sp3-card\">\n        <div class=\"sp3-card-icon\">\u2697\ufe0f<\/div>\n        <h3>Toxicology & safety<\/h3>\n        <p>Hepatotoxicity, nephrotoxicity, cardiotoxicity \u2014 3D spheroid models from primary cells or organotypic cultures provide more accurate safety assessment than 2D monolayers.<\/p>\n      <\/div>\n      <div class=\"sp3-card\">\n        <div class=\"sp3-card-icon\">\ud83c\udf31<\/div>\n        <h3>Stem cell & organoid research<\/h3>\n        <p>Embryoid bodies, neurospheres, and early-stage organoids \u2014 all visible and quantifiable in brightfield time-lapse without disrupting the culture environment.<\/p>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/div>\n\n<!-- VALIDATED EXPERIMENTS -->\n<div class=\"sp3-w\">\n  <div class=\"sp3-label\">Validated Experimental Data<\/div>\n  <h2 class=\"sp3-h2\">Two Validated Spheroid Workflows \u2014 <span>Real Results<\/span><\/h2>\n  <p class=\"sp3-lead\">Published in collaboration with the University of Regensburg and Fraunhofer EMFT Munich. Both experiments run fully automated inside the incubator with zenCELL owl.<\/p>\n\n  <div class=\"sp3-exp-grid\">\n\n    <!-- EXPERIMENT 1 -->\n    <div class=\"sp3-exp-card\">\n      <div class=\"sp3-exp-header\">\n        <h3>Experiment 1 \u2014 Spheroid Proliferation<\/h3>\n        <p>Non-adhesive surface \u00b7 MCF-7 breast cancer cells<\/p>\n      <\/div>\n      <div class=\"sp3-exp-img\">\n        <img decoding=\"async\" src=\"https:\/\/zencellowl.com\/wp-content\/uploads\/2025\/06\/diameter.webp\"\n             alt=\"MCF-7 spheroid growth monitoring \u2014 diameter over 96 hours brightfield zenCELL owl\">\n      <\/div>\n      <div class=\"sp3-exp-body\">\n        <div class=\"sp3-exp-specs\">\n          <div class=\"sp3-exp-spec\"><span class=\"k\">Platform<\/span><span class=\"v\">Agarose-coated 24-well plate<\/span><\/div>\n          <div class=\"sp3-exp-spec\"><span class=\"k\">Cell line<\/span><span class=\"v\">MCF-7 \u00b7 6,000 cells\/well<\/span><\/div>\n          <div class=\"sp3-exp-spec\"><span class=\"k\">Duration<\/span><span class=\"v\">96 hours<\/span><\/div>\n          <div class=\"sp3-exp-spec\"><span class=\"k\">Interval<\/span><span class=\"v\">Every 10 minutes<\/span><\/div>\n        <\/div>\n        <div class=\"sp3-exp-result\">\u2713 Spheroids formed smooth, round shapes. Proliferation in outer layers increased diameter over time. Area, width, height, and roundness quantified automatically \u2014 no manual measurements.<\/div>\n      <\/div>\n    <\/div>\n\n    <!-- EXPERIMENT 2 -->\n    <div class=\"sp3-exp-card\">\n      <div class=\"sp3-exp-header\">\n        <h3>Experiment 2 \u2014 Adhesion & Outgrowth<\/h3>\n        <p>Treated surface \u00b7 7-day-old MCF-7 spheroids<\/p>\n      <\/div>\n      <div class=\"sp3-exp-img\">\n        <img decoding=\"async\" src=\"https:\/\/zencellowl.com\/wp-content\/uploads\/2025\/06\/cellular-spheroid-with-migrating-monolayer.webp\"\n             alt=\"Spheroid adhesion and outgrowth monitoring \u2014 migrating monolayer brightfield zenCELL owl\">\n      <\/div>\n      <div class=\"sp3-exp-body\">\n        <div class=\"sp3-exp-specs\">\n          <div class=\"sp3-exp-spec\"><span class=\"k\">Platform<\/span><span class=\"v\">TC-treated 24-well plate<\/span><\/div>\n          <div class=\"sp3-exp-spec\"><span class=\"k\">Spheroids<\/span><span class=\"v\">7-day-old \u00b7 6,000 cells\/well<\/span><\/div>\n          <div class=\"sp3-exp-spec\"><span class=\"k\">Duration<\/span><span class=\"v\">48 hours<\/span><\/div>\n          <div class=\"sp3-exp-spec\"><span class=\"k\">Interval<\/span><span class=\"v\">Every 10 minutes<\/span><\/div>\n        <\/div>\n        <div class=\"sp3-exp-result\">\u2713 Cells adhered and began migrating outward. Semi-spherical 3D core with surrounding monolayer formed within 48 hours. Full adhesion and outgrowth dynamics captured automatically.<\/div>\n      <\/div>\n    <\/div>\n\n  <\/div>\n<\/div>\n\n<!-- WHAT YOU MEASURE -->\n<div style=\"background:var(--off);\">\n  <div class=\"sp3-w\">\n    <div class=\"sp3-label\">Brightfield Spheroid Metrics<\/div>\n    <h2 class=\"sp3-h2\">What zenCELL owl Measures <span>Automatically<\/span><\/h2>\n    <p class=\"sp3-lead\">All metrics calculated automatically from brightfield images \u2014 no staining, no manual measurement, no operator variability.<\/p>\n    <div class=\"sp3-metrics\">\n      <div class=\"sp3-metric\">\n        <div class=\"sp3-metric-icon\">\ud83d\udcd0<\/div>\n        <h4>Spheroid diameter & area<\/h4>\n        <p>Continuous growth curves \u2014 diameter and projected area at every imaging interval. Full kinetic growth profile from T0 to endpoint.<\/p>\n      <\/div>\n      <div class=\"sp3-metric\">\n        <div class=\"sp3-metric-icon\">\u2b55<\/div>\n        <h4>Roundness & morphology<\/h4>\n        <p>Compact vs. irregular spheroid morphology quantified as roundness score. Drug-induced morphology changes detected automatically.<\/p>\n      <\/div>\n      <div class=\"sp3-metric\">\n        <div class=\"sp3-metric-icon\">\ud83d\udccf<\/div>\n        <h4>Width & height<\/h4>\n        <p>Orthogonal dimensions tracked over time \u2014 useful for spheroids with non-circular cross-sections or directional growth patterns.<\/p>\n      <\/div>\n      <div class=\"sp3-metric\">\n        <div class=\"sp3-metric-icon\">\ud83d\udd04<\/div>\n        <h4>Outgrowth area<\/h4>\n        <p>For adhesion assays: migrating cell monolayer area quantified separately from the spheroid core \u2014 outgrowth rate per timepoint.<\/p>\n      <\/div>\n      <div class=\"sp3-metric\">\n        <div class=\"sp3-metric-icon\">\u23f1<\/div>\n        <h4>Growth rate kinetics<\/h4>\n        <p>Rate of diameter increase per hour \u2014 comparable across 24 conditions. Drug response onset: exact timepoint when growth slows or reverses.<\/p>\n      <\/div>\n      <div class=\"sp3-metric\">\n        <div class=\"sp3-metric-icon\">\ud83c\udfac<\/div>\n        <h4>Time-lapse video export<\/h4>\n        <p>AVI time-lapse per well, PNG image stack for ImageJ, CSV kinetic data for GraphPad Prism or R. All export formats publication-ready.<\/p>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/div>\n\n<!-- PROTOCOL -->\n<div class=\"sp3-w\">\n  <div class=\"sp3-label\">Step-by-Step Protocol<\/div>\n  <h2 class=\"sp3-h2\">Spheroid Monitoring with zenCELL owl \u2014 <span>Setup in Under 10 Minutes<\/span><\/h2>\n  <p class=\"sp3-lead\">Works with agarose-coated plates, ULA plates, Matrigel domes, and standard TC-treated plates. No protocol modifications required.<\/p>\n  <div class=\"sp3-steps\">\n    <div class=\"sp3-step\">\n      <div class=\"sp3-step-num\">1<\/div>\n      <div>\n        <h4>Prepare spheroid plate<\/h4>\n        <p>Form spheroids using your preferred method \u2014 agarose-coated plates, ULA 96-well, or hanging drop. Transfer to 24-well format at desired size (typically after 3\u20137 days of formation).<\/p>\n        <span class=\"sp3-badge\">Standard spheroid protocol<\/span>\n      <\/div>\n    <\/div>\n    <div class=\"sp3-step\">\n      <div class=\"sp3-step-num\">2<\/div>\n      <div>\n        <h4>Place zenCELL owl inside incubator<\/h4>\n        <p>Place zenCELL owl on the incubator shelf. Connect USB-C to PC outside the incubator. Setup takes under 2 minutes \u2014 no engineers, no dedicated incubator required.<\/p>\n        <span class=\"sp3-badge\">\u23f1 Under 2 minutes<\/span>\n      <\/div>\n    <\/div>\n    <div class=\"sp3-step\">\n      <div class=\"sp3-step-num\">3<\/div>\n      <div>\n        <h4>Place plate and configure imaging<\/h4>\n        <p>Place 24-well plate on zenCELL owl. Select wells, set imaging interval (10 minutes recommended for spheroids), and experiment duration (up to 14 days). AI autofocus calibrates per well.<\/p>\n        <span class=\"sp3-badge\">\u23f1 Under 5 minutes<\/span>\n      <\/div>\n    <\/div>\n    <div class=\"sp3-step\">\n      <div class=\"sp3-step-num\">4<\/div>\n      <div>\n        <h4>Start \u2014 system runs unattended<\/h4>\n        <p>zenCELL owl captures brightfield images of all selected wells at every interval. Monitor remotely from any PC. Receive automatic alerts at defined size thresholds.<\/p>\n        <span class=\"sp3-badge\">Fully automated \u00b7 24\/7<\/span>\n      <\/div>\n    <\/div>\n    <div class=\"sp3-step\">\n      <div class=\"sp3-step-num\">5<\/div>\n      <div>\n        <h4>Analyse and export<\/h4>\n        <p>zenCELL owl software automatically calculates diameter, area, roundness and outgrowth per well over time. Export CSV kinetic data, AVI time-lapse, PNG stack. Full ImageJ compatibility.<\/p>\n        <span class=\"sp3-badge\">CSV \u00b7 AVI \u00b7 PNG \u00b7 ImageJ<\/span>\n      <\/div>\n    <\/div>\n  <\/div>\n\n  <div class=\"sp3-highlight\">\n    <p><strong>96-well spheroid screening<\/strong> is possible with the zenCELL owl XYZ SCAN stage add-on \u2014 automated multi-position imaging across a full 96-well ULA plate in under 90 seconds per scan. Contact us for specifications.<\/p>\n    <div class=\"sp3-hl-stat\"><div class=\"n\">24<\/div><div class=\"u\">Wells \u00b7 one experiment<\/div><\/div>\n    <div class=\"sp3-hl-stat\"><div class=\"n\">&lt;90s<\/div><div class=\"u\">Full 96-well scan (XYZ)<\/div><\/div>\n    <div class=\"sp3-hl-stat\"><div class=\"n\">14 days<\/div><div class=\"u\">Max. duration<\/div><\/div>\n  <\/div>\n<\/div>\n\n<!-- COMPARISON -->\n<div style=\"background:var(--off);\">\n  <div class=\"sp3-w\">\n    <div class=\"sp3-label\">Comparison<\/div>\n    <h2 class=\"sp3-h2\">zenCELL owl vs. <span>Manual Spheroid Monitoring vs. Incucyte<\/span><\/h2>\n    <div class=\"sp3-table-wrap\">\n      <table class=\"sp3-table\">\n        <thead>\n          <tr>\n            <th>Feature<\/th>\n            <th>zenCELL owl<\/th>\n            <th>Manual Microscopy<\/th>\n            <th>Incucyte S3<\/th>\n          <\/tr>\n        <\/thead>\n        <tbody>\n          <tr><td>Continuous monitoring<\/td><td class=\"sp3-ok\">\u2713 Every 10 min \u00b7 14 days<\/td><td class=\"sp3-red\">\u2717 Manual timepoints only<\/td><td class=\"sp3-ok\">\u2713 Yes<\/td><\/tr>\n          <tr><td>Inside incubator<\/td><td class=\"sp3-ok\">\u2713 Any CO\u2082 incubator<\/td><td class=\"sp3-red\">\u2717 Plate removed each time<\/td><td class=\"sp3-mute\">Dedicated incubator needed<\/td><\/tr>\n          <tr><td>Wells simultaneously<\/td><td class=\"sp3-ok\">24 (96 with XYZ)<\/td><td class=\"sp3-red\">1 at a time<\/td><td class=\"sp3-mute\">Up to 6 positions<\/td><\/tr>\n          <tr><td>Fluorescence<\/td><td class=\"sp3-mute\">No \u2014 brightfield only<\/td><td class=\"sp3-ok\">Yes<\/td><td class=\"sp3-ok\">Yes \u2014 3 channels<\/td><\/tr>\n          <tr><td>Label-free<\/td><td class=\"sp3-ok\">\u2713 No dyes needed<\/td><td class=\"sp3-mute\">Depends on assay<\/td><td class=\"sp3-ok\">\u2713 Brightfield available<\/td><\/tr>\n          <tr><td>Automated analysis<\/td><td class=\"sp3-ok\">\u2713 Diameter \u00b7 area \u00b7 roundness<\/td><td class=\"sp3-red\">\u2717 Manual ImageJ<\/td><td class=\"sp3-ok\">\u2713 Spheroid module<\/td><\/tr>\n          <tr><td>Price<\/td><td class=\"sp3-ok\">from \u20ac14,000 \u00b7 no annual fee<\/td><td class=\"sp3-ok\">~\u20ac0 (existing microscope)<\/td><td class=\"sp3-red\">~\u20ac220,000 + annual fee<\/td><\/tr>\n          <tr><td>Installation<\/td><td class=\"sp3-ok\">Any incubator \u00b7 &lt;10 min<\/td><td class=\"sp3-mute\">Standard microscope setup<\/td><td class=\"sp3-red\">Dedicated incubator required<\/td><\/tr>\n        <\/tbody>\n      <\/table>\n    <\/div>\n  <\/div>\n<\/div>\n\n<!-- REFERENCE -->\n<div class=\"sp3-w\">\n  <div class=\"sp3-label\">Peer-Reviewed Validation<\/div>\n  <h2 class=\"sp3-h2\">Validated at Leading <span>DACH Research Institutions<\/span><\/h2>\n  <p class=\"sp3-lead\">zenCELL owl spheroid monitoring has been validated and published in collaboration with two of Germany's leading life science research institutions.<\/p>\n\n  <div class=\"sp3-ref\">\n    <div class=\"sp3-ref-icon\">\ud83c\udfdb<\/div>\n    <div class=\"sp3-ref-text\">\n      <h4>University of Regensburg & Fraunhofer EMFT Munich<\/h4>\n      <p>Joint application note: timelapse imaging of MCF-7 spheroids \u2014 96-hour growth monitoring, morphological quantification, adhesion and outgrowth dynamics. Published with support from distribution partner Omni Life Science. Available as free PDF download.<\/p>\n    <\/div>\n  <\/div>\n\n  <div style=\"margin-top:16px; text-align:center;\">\n    <a href=\"https:\/\/zencellowl.com\/wp-content\/uploads\/2023\/02\/zencell-owl_Application-Note-Time-lapse-imaging-of-spheroids.pdf\" target=\"_blank\" class=\"sp3-btn\">Download Application Note PDF \u2192<\/a>\n  <\/div>\n\n  <!-- RELATED -->\n  <div style=\"margin-top:56px;\">\n    <div class=\"sp3-label\">Related Applications<\/div>\n    <div class=\"sp3-related\">\n      <a href=\"https:\/\/zencellowl.com\/organoid-live-cell-imaging\/\" class=\"sp3-rel\">\n        <div class=\"sp3-rel-tag\">3D Models<\/div>\n        <h4>Organoid Live Cell Imaging<\/h4>\n        <p>Brain, cardiac, liver, intestinal and patient-derived organoids \u2014 continuous monitoring for up to 14 days without disruption.<\/p>\n      <\/a>\n      <a href=\"https:\/\/zencellowl.com\/cytotoxicity-assay\/\" class=\"sp3-rel\">\n        <div class=\"sp3-rel-tag\">Drug Screening<\/div>\n        <h4>Cytotoxicity & Drug Response<\/h4>\n        <p>Kinetic dose-effect data from 3D spheroid drug treatment \u2014 growth inhibition curves without endpoint staining.<\/p>\n      <\/a>\n      <a href=\"https:\/\/zencellowl.com\/brightfield-live-cell-imaging\/\" class=\"sp3-rel\">\n        <div class=\"sp3-rel-tag\">Technology<\/div>\n        <h4>Brightfield Live Cell Imaging Hub<\/h4>\n        <p>All zenCELL owl applications \u2014 scratch assay, cell migration, organoids, cytotoxicity, time-lapse \u2014 in one overview.<\/p>\n      <\/a>\n    <\/div>\n  <\/div>\n<\/div>\n\n<!-- FAQ -->\n<div style=\"background:var(--off);\">\n  <div class=\"sp3-w\">\n    <div class=\"sp3-label\">FAQ<\/div>\n    <h2 class=\"sp3-h2\">Spheroid Imaging \u2014 <span>Common Questions<\/span><\/h2>\n    <div class=\"sp3-faq\">\n      <details open>\n        <summary>What plate formats are compatible with zenCELL owl for spheroid imaging?<\/summary>\n        <p>zenCELL owl is compatible with standard 24-well plates \u2014 including agarose-coated plates, tissue culture-treated plates, and standard flat-bottom plates with ULA coating. For 96-well ULA plates, the XYZ SCAN stage add-on enables full-plate automated imaging. Matrigel dome cultures in 24-well format are also compatible. Contact us for plate-specific recommendations.<\/p>\n      <\/details>\n      <details>\n        <summary>Do I need fluorescence to image spheroids with zenCELL owl?<\/summary>\n        <p>No. For growth monitoring, morphology tracking, size quantification, and drug response kinetics \u2014 brightfield is sufficient. Fluorescence is required for specific viability dyes (calcein AM, propidium iodide), GFP reporter lines, or multiplexed readouts. For brightfield-compatible spheroid assays, zenCELL owl provides a complete label-free solution at significantly lower cost than fluorescence systems.<\/p>\n      <\/details>\n      <details>\n        <summary>How small can spheroids be to still be detected by zenCELL owl?<\/summary>\n        <p>zenCELL owl reliably detects spheroids from approximately 100\u2013150 \u00b5m diameter upwards. Early-stage aggregates below 100 \u00b5m may have lower contrast in brightfield. For very small aggregates, contact us to discuss your specific application \u2014 imaging parameters can be adjusted to optimize contrast for your cell line and plate format.<\/p>\n      <\/details>\n      <details>\n        <summary>Can I monitor spheroid drug response kinetics with zenCELL owl?<\/summary>\n        <p>Yes \u2014 this is one of the most common applications. Add compound to spheroid wells after formation, and monitor the effect on growth, morphology, and viability continuously over 24\u201396 hours across 24 conditions simultaneously. The continuous kinetic data reveals onset of drug effect, growth arrest, and recovery \u2014 not just a before\/after comparison.<\/p>\n      <\/details>\n      <details>\n        <summary>What is the difference between zenCELL owl and Incucyte for spheroid imaging?<\/summary>\n        <p>For brightfield spheroid growth monitoring, zenCELL owl covers the same core assay at over 90% lower cost. Key differences: zenCELL owl fits inside any existing CO\u2082 incubator (Incucyte S3 requires a dedicated incubator), has no annual licence fee, and includes free ImageJ integration. Incucyte S3 adds fluorescence channels and a larger validated assay library. For label-free spheroid growth monitoring, zenCELL owl is the cost-effective alternative.<\/p>\n      <\/details>\n    <\/div>\n  <\/div>\n<\/div>\n\n<!-- CTA -->\n<section class=\"sp3-cta\">\n  <h2>Monitor Your Spheroids Continuously<\/h2>\n  <p>Free 20-minute remote demo \u2014 real spheroids, real incubator, full software. Twice a week via MS Teams.<\/p>\n  <a href=\"https:\/\/zencellowl.com\/live-remotedemo\/\" class=\"sp3-btn\">Book Free Demo<\/a>\n  <a href=\"https:\/\/zencellowl.com\/wp-content\/uploads\/2023\/02\/zencell-owl_Application-Note-Time-lapse-imaging-of-spheroids.pdf\" target=\"_blank\" class=\"sp3-btn sp3-btn-ghost\">Download Application Note \u2192<\/a>\n<\/section>\n\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f75fff1 e-flex e-con-boxed e-con e-parent\" data-id=\"f75fff1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-fbe277b e-con-full e-flex e-con e-child\" data-id=\"fbe277b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-05d2f01 elementor-widget elementor-widget-heading\" data-id=\"05d2f01\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Developed in collaboration with:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-78fadd0 elementor-widget elementor-widget-text-editor\" data-id=\"78fadd0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>University of Regensburg &amp; Fraunhofer EMFT, Munich<\/strong><br \/>With support from our distribution partner<strong> Omni Life Science (www.ols-bio.com)<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>zenCELL owl \u00b7 Spheroid &#038; 3D Cell Culture Spheroid Live Cell Imaging \u2014 Continuous, Inside Your Incubator Monitor spheroid growth, morphology, drug response and outgrowth dynamics continuously \u2014 brightfield, label-free, [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":3993,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3985","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Spheroid Timelapse Imaging \u2014 3D Cell Culture | zenCELL owl<\/title>\n<meta name=\"description\" content=\"Real-time timelapse monitoring of spheroids inside the incubator. 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